Table 1: Baseline Characteristics of Study Participants

Fenofibrate Plus UDCA (n=6) UDCA (n=4) p Reference Range
Mean duration of UDCA monotherapy (months) 8.6±0.8 8.8±0.7 NS
Age (years) 55.3±4.5 54.8±7.3 NS
Sex (male/female) 1/5 1/3 NS
Smoking (yes/no) 2/4 1/3 NS
Body mass index (kg/m2) 27.2±2.8 27.9±3.1 NS
ALP (IU/L) 195±73 232±74 NS 30-125
AST (IU/L) 42±15 38±10 NS 10-35
ALT (IU/L) 49±25 41±13 NS 10-35
γGT (IU/L) 96 (38-479) 112 (56-419) NS 10-52
Total bilirubin (mg/dL) 0.70±0.14 0.73±0.18 NS 0.1-1.0
Conjugated bilirubin (mg/dL) 0.16±0.04 0.17±0.07 NS 0.0-0.3
Uric acid (mg/dL) 4.3±1.3 4.1±1.2 NS 3.4-8.0 (men) 2.4-6.1 (women)
Creatinine (mg/dL) 0.74±0.15 0.76±0.12 NS 0.6-1.2
Amylase (IU/L) 63±15 68±16 NS 30-90
Total cholesterol (mg/dL) 283±40 302±45 NS 110-200
Triglycerides (mg/dL) 145±67 136±68 NS 40-175
HDL-C (mg/dL) 68±17 71±18 NS 35-70
LDL-C (mg/dL) 189±29 198±24 NS Target values depend on individual cardiovascular risk
non HDL-C (mg/dL) 215±27 221±29 NS
Glucose (mg/dL) 96±19 92±16 NS 70-125

UDCA: ursodeoxycholic acid, ALP: alkaline phosphatase, AST: aspartate aminotransferase, ALT: alanine aminotransferase, γGT: gamma glutamyl transpeptidase, HDL-C: high density lipoprotein cholesterol, LDL-C: low density lipoprotein cholesterol, NS: not significantValues are expressed as mean ± SD, except for γGT which is expressed as median (range)To convert bilirubin values to µmol/L multiply by 17.1. To convert uric acid values to µmol/L multiply by 59.48. To convert creatinine values to µmol/L multiply by 88.4. To convert cholesterol values to mmol/L multiply by 0.026. To convert triglyceride values to mmol/L multiply by 0.0113. To convert glucose values to mmol/L multiply by 0.05551.