Genes |
SNP |
rsID |
Vascular Events |
Surrogate Biomarkers |
IL6 |
-174G>C |
rs1800795 |
CAD/MI [22, 26, 27] |
High plasma IL6 levels [24] |
|
|
|
CIMT [32] |
High CRP levels [22, 52, 53, 55] |
|
|
|
PAD [33] |
High Systolic Blood pressure [27] |
|
|
|
|
Increased arterial stiffness[28] |
|
|
|
|
Insulin insensitivity [84] |
|
|
|
|
Lipid abnormalities [34] |
|
-572G>C |
rs1800796 |
CAD / MI [38] |
High plasma IL6 levels [24] |
|
|
|
|
Plasma IL6, CRP, Fibrinogen [54] |
CRP |
+1444C>T |
rs3091244 |
CAD [46] |
High plasma CRP levels [42, 45, 52, 85, 86] |
|
|
|
Stroke [87] |
Hypertension [47] |
|
|
|
|
Obesity [50] |
|
|
rs3093058 |
|
High Plasma CRP levels [86] |
|
|
rs3091244 |
|
High Plasma CRP levels [49] |
|
|
rs1800947 |
Arterial pulse-wave velocity [49] |
|
TNF-α |
-308G>A |
rs3091256 |
CAD [58, 60, 61, 66, 67] |
|
|
|
|
|
Obesity [63] |
|
|
|
|
Insulin resistance [64] |
|
|
|
|
Metabolic syndrome [62] |
|
|
|
|
Plasma CRP levels [65] |
CAD – Coronary Artery Disease, CIMT – Carotid Intima Media Thickness, CRP- C-reactive protein, IL 6 – Interleukin 6, MI- Myocardial Infarction, PAD – Peripheral Arterial Disease, SNP – Single Nucleotide Polymorphism, TNF- α – Tumor necrosis factor-alpha.Note: References given in brackets.