Table 1: Overview of Genotype-Phenotype Association of some key Inflammatory Genes Variants

Genes SNP rsID Vascular Events Surrogate Biomarkers
IL6 -174G>C rs1800795 CAD/MI [22, 26, 27] High plasma IL6 levels [24]
CIMT [32] High CRP levels [22, 52, 53, 55]
PAD [33] High Systolic Blood pressure [27]
Increased arterial stiffness[28]
Insulin insensitivity [84]
Lipid abnormalities [34]
-572G>C rs1800796 CAD / MI [38] High plasma IL6 levels [24]
Plasma IL6, CRP, Fibrinogen [54]
CRP +1444C>T rs3091244 CAD [46] High plasma CRP levels [42, 45, 52, 85, 86]
Stroke [87] Hypertension [47]
Obesity [50]
rs3093058 High Plasma CRP levels [86]
rs3091244 High Plasma CRP levels [49]
rs1800947 Arterial pulse-wave velocity [49]
TNF-α -308G>A rs3091256 CAD [58, 60, 61, 66, 67]
Obesity [63]
Insulin resistance [64]
Metabolic syndrome [62]
Plasma CRP levels [65]

CAD – Coronary Artery Disease, CIMT – Carotid Intima Media Thickness, CRP- C-reactive protein, IL 6 – Interleukin 6, MI- Myocardial Infarction, PAD – Peripheral Arterial Disease, SNP – Single Nucleotide Polymorphism, TNF- α – Tumor necrosis factor-alpha.Note: References given in brackets.