Table 1: Factors Involved in Thrombogenesis in BD and Possible Therapeutic Measures

Factors of Thrombogenesis in BD Therapeutic Measures
Blood flow abnormalities Enhanced erythrocyte aggregation, increased fibrinogen, high blood viscosity
Impaired microcirculation
Turbulent blood flow at sites of venous varices and arterial aneurysms
Arterial and venous occlusion
Immunosuppressive drugs
Aspirin
Heparin (?)
Warfarin (?)
Abnormal vessel wall Perivasculitis
Endothelial dysfunction
Venous varices
Aneurysms and pseudoaneurysms
Immunosuppressive drugs
Angioplasty (?)
Abnormal blood constituents Endothelial factors (increase/decrease of vWF, t-PA, thrombomodulin,
NO, VEGF, endothelin-1)
Procoagulant factors [factor V Leiden and prothrombin mutations,
hyperhomocystenemia, factors VIII, IX, lipoprotein (a)]
Factors of fibrinolysis increase/decrease of TAFI, PAI-1, t-PA
Anticoagulant factors (protein C, S, Z, TFPI, antithrombin)
Platelets hyperactivity
Immunosuppressive drugs

Heparin (?)

Warfarin (?)

Aspirin