Factors of Thrombogenesis in BD | Therapeutic Measures | |
---|---|---|
Blood flow abnormalities | Enhanced erythrocyte aggregation, increased fibrinogen, high blood viscosity Impaired microcirculation Turbulent blood flow at sites of venous varices and arterial aneurysms Arterial and venous occlusion |
Immunosuppressive drugs Aspirin Heparin (?) Warfarin (?) |
Abnormal vessel wall | Perivasculitis Endothelial dysfunction Venous varices Aneurysms and pseudoaneurysms |
Immunosuppressive drugs Angioplasty (?) |
Abnormal blood constituents | Endothelial factors (increase/decrease of vWF, t-PA, thrombomodulin, NO, VEGF, endothelin-1) Procoagulant factors [factor V Leiden and prothrombin mutations, hyperhomocystenemia, factors VIII, IX, lipoprotein (a)] Factors of fibrinolysis increase/decrease of TAFI, PAI-1, t-PA Anticoagulant factors (protein C, S, Z, TFPI, antithrombin) Platelets hyperactivity |
Immunosuppressive drugs Heparin (?) Warfarin (?) Aspirin |