| Disease | Dna Damage | Comment |
|---|---|---|
| Acute Lymphoblastic leukemia | FapyGua, 8-OH-Gua, FapyAde, 8-OHAde, 5-OH-Cyt, 5-OH-5-MeHyd, 5-OH-Hyda(DNA |
Significant increase in DNA damage level in ALL in comparison to control (p < 0.05) [20]. |
| Parkinson's disease | 8-OH-dG 8-OH-Guo (DNA/RNA) |
Significant increase in 8-OH-dG level (p = 0.0002) in grey matter of brain [21]. |
| Alzheimer's disease | 8-OH-dG | Higher 8-0H-dG level in cortex and cerebellum [22]. |
| Amyotrophic lateral sclerosis | 8-OH-dG | Significant increase in 8-OH-dG level in comparison to control [23]. |
| Primary breast cancer | 8-OH-dG (DNA) | Increased 8-OH-dG level ( p< 0.0001) in carcinoma tissues in comparison to normal tissues [24]. |
| Cardiovascular diseases | 8-OH-dG (DNA) | Increased 8-OH-dG level in lymphocytes (p < 0.01) in ischaemic heart disease [25]. |
| Colorectal carcinoma | 8-OH-dG (DNA) | Significant increase in 8-OH-dG level in carcinoma tissue in comparison to normal mucous membrane [26]. |
| Gynecological neoplasms | 8-OH-dG (urine) | Significant increase in 8-OH-dG level (p < 0.05) in patients with cancer in relation to control [25]. |
| Cervical carcinoma | 8-OH-dG (DNA) | Significant increase in 8-OH-dG level in comparison to control [27]. |
| Renal cell carcinoma | 8-OH-dG (DNA) | Significant increase in 8-OH level (p < 0.0005) in tissues changed in comparison to normal tissues [28]. |
| Chronic liver disease | 8-OH-dG (DNA) | Significant increase in 8-OH-dG level (p < 0.05) in comparison to control [29]. |
| HCV | 8-OH-dG (DNA) | Significant increase in 8-OH-dG level ( p< 0.001) in comparison to control [30]. |
| Cystic fibrosis | 8-OH-dG (urine) | Increased level of 8-OH-dG in comparison to control [31]. |
| Small cell lung carcinoma | 8-OH-dG (urine) | Increase in 8-OH-dG level in comparison to control (p < 0.05) [32]. |
| Pulmonary carcinoma | 8-OH-dG (DNA) | Increase in 8-OH-dG level in lymphocytes and carcinoma tissues [33]. |
| Atopic dermatitis | 8-OH-dG (urine) | Increase in 8-OH-dG level (p < 0.0001) in comparison to control [34]. |
| Gastric adenoma | 8-OH-dG (DNA) | Significant increase in 8-OH-dG level in cancer tissues in comparison to normal tissues [35]. |
| Type I and II diabetes | 8-OH-dG (urine) | Level of 8-OH-dG in patients with type I and II diabetes significantly increased in comparison to control [36]. |
| Down syndrome | 8-OH-dG (urine) | Increase of 8-OH-dG level in patients in comparison to control [37]. |
| Rheumatoid arthritis | 8-OH-dG (urine) | Increase of 8-OH-dG level ( p< 0.001) in comparison to control [38]. |
| Chronic venous disease | 8-OH-dG (DNA) | Increase of 8-OH-dG level (p < 0.00001) in comparison to control [own studies] |