| Type of Cardiorenal Syndrome | Definition | Primary Event |
|---|---|---|
Acute cardio-renal
(type 1) (20–25%) 
|
Acute worsening of heart function (AHF–ACS) leading to kidney injury and/or dysfunction | Acute heart failure (AHF) or acute coronary syndrome (ACS) or cardiogenic shock |
Chronic cardio-renal
(type 2)
(30–45%) 
|
Chronic abnormalities in heart function (CHF-CHD) leading to kidney injury or dysfunction | Chronic heart disease (systolic and/or diastolic dysfunction, chronic abnormalities in cardiac function, cardiomyopathy) |
Acute reno-cardiac (type 3) (30–35%) 
|
Acute worsening of kidney function leading to heart injury and/or dysfunction | Acute kidney injuring (AKI) |
Chronic reno-cardiac (type 4) (45–50%) 
|
Chronic kidney disease (CKD) leading to heart injury, disease and/or dysfunction | CKD |
Secondary cardio-renal (type 5) 
|
Systemic condition causing cardiac and renal dysfunction | Systemic disease (septic shock, diabetes, MetS, NAFLD, amyloidosis, vasculitis etc.) |
AHF = Acute heart failure, ACS = acute coronary syndrome, AKI = acute kidney injury, CKD = chronic kidney disease, MetS = Metabolic syndrome, NAFLD = non alcoholic fatty liver disease.