| Author, Year |
No of patients |
Control Group/ Adherence to CPAP (h/night) |
Baseline Lipid Profile |
Age (Years) |
BMI
(Kg/m2) |
AHI(/h) |
ESS |
Duration |
Methods |
Results |
| Chin et al. 1999 |
22 |
No body weight reduction (n=13),
body weight reduction (n=9) |
|
NBWR: 46.2±3.7,
BWR: 50.8±3.7 |
NBWR: 28.5±0.8,
BWR:31.2±1.7 |
NBWR: 52.7±5,
BWR: 63.5±5.8 |
|
8 months |
TC,
triglycerides, HDL-C,
LDL-C, apoA-I, apoA-II, apoB, apoC-II,
apoC-III, apoE |
NBWR:
improvement
in HDL-C and LDL-C
BWR: improvement in
triglycerides, HDL-C, LDL-C, apoA-II, apoC-II |
| Ip et al.
2000 |
60 |
Yes |
|
OSA:
43.6±10.1
control: 41.9±10.4 |
OSA:
27± 2.9
control:
26.5± 2.1 |
35.7±18
1.8±1.9 |
|
6 months |
TC,
triglycerides, HDL-C, LDL-C, TC/HDL-C ratio |
Decrease in triglycerides levels after CPAP treatment |
| Buechner
et al.
2001 |
95 |
Effective treated group/ ineffective treated group |
LDL-C levels ≥ 130 mg/dl |
56.6±9.5 |
|
|
|
6 months |
TC,
triglycerides, HDL-C,
LDL-C, apoB, and lipoprotein (a) levels |
Decrease in TC and LDL-C in effective treated group |
| Robinson
et al.
2004 |
220
|
Yes/
Subtherapeutic CPAP 4.1±2.4, therapeutic CPAP 5.0±1.9 |
Mean baseline levels of TC within the
normal range in both groups |
49.1±10.3
49.7± 10.3 |
35.9±6.3
35.6±7.6 |
Oxygen saturation dips 4%
(per hour of sleep):
38.5±20.3
38.9±21.1 |
16.2±3.3
16.3±3.3 |
1 year |
TC,
triglycerides |
Reduction in TC in therapeutic CPAP group |
| Borgel et al. 2006 |
127 |
|
9.4% were under lipid lowering medication |
55.7±10.6 |
31.6±5.9 |
32.9±.21.5 |
|
6 months |
TC,
triglycerides, HDL-C,
LDL-C |
Improvement in TC, triglycerides, HDL-C, LDL-C levels in patients with initial abnormal
lipids levels |
| Dorkova et al.
2008 |
32 |
No/
Good adherence group (5.1±1.2)
Poor adherence group (1.9±1.1)
|
|
53.7±9.6 |
35.1±6.1 |
64±20.8 |
13.3±4.6 |
8 weeks |
TC
triglycerides, HDL-C ,LDL-C, apoA-I, apoB |
Reduction in TC and apoB in the good adherence group |
| Barcelo et al.
2008 |
44 |
Yes/
OSA with EDS (n=22), OSA without EDS (n=22) |
|
|
|
|
|
3 months |
TC,
triglycerides |
Reduction in TC in patients with EDS |
| Oktay et al.
2009 |
20
|
No |
|
50±7.74
|
|
|
|
1 year |
|
Increase in
HDL-C |
| Cuhadaroglu et al.
2009 |
31 |
Mean CPAP use
>4h/night |
|
Range: 28-76 |
32.3±4.7 |
Range 16-90 |
11.3±5.7 |
8 weeks |
TC,
triglycerides, HDL-C, LDL-C, VLDL-C |
Reduction in TC and LDL-C |
| Author, Year |
No of patients |
Control Group/ Adherence to CPAP (h/night) |
Baseline Lipid Profile |
Age (Years) |
BMI
(Kg/m2) |
AHI(/h) |
ESS |
Duration |
Methods |
Results |
| Steiropoulos et al.
2009 |
53 |
Good adherence group
(n=20)
Poor adherence group
(n=19)
No CPAP group
(n=14) |
Elevated TC levels (81.1%), elevated
triglycerides levels (45.3%), elevated LDL-C levels (26.4%), low HDL-C levels (30.2%) |
46.09±10.87 |
34.05±7.09 |
56.9±26.82 |
11.42±5.78 |
6 months |
TC,
triglycerides, HDL-C, LDL-C, TC/HDL-C ratio,
apoA-I, apoB, apoB/apoA-I ratio |
Reduction in TC, TC/HDL-C ratio and apoB/apoA-I ratio in the good adherence group |
Abbreviations: AHI = apnea-hypopnea index, apo = apolipoprotein, BMI = body mass index, CPAP = continuous positive airway pressure, EDS = excessive daytime sleepiness,
HDL-C=high density lipoprotein cholesterol, LDL-C=low density lipoprotein cholesterol, TC = total cholesterol.