Agent | Adverse Effect on The Lipid Profile | Reference |
---|---|---|
Non-selective beta blockers | ↑ TG levels ↓ HDL-C levels |
[5, 6, 14, 15] |
Beta1-selective blockers | ↑ TG levels (no effect or ↓ in other studies) | [5, 7-15] |
Nebivolol | ↓ HDL-C levels (no effect in other studies) | [8, 13, 15] |
Hydrochlorothiazide (≥ 25 mg/day) | ↑ TG levels ↑ TC levels |
[6, 22] |
Chlorthalidone | ↑ LDL-C levels | [6] |
Indapamide | ↑ LDL-C levels (no effect in other studies) | [6, 21, 24] |
Pioglitazone | ↑ LDL-C levels | [46, 47] |
Rosiglitazone | ↑ LDL-C levels ↑ TG levels |
[46, 47] |
Orlistat | ↓ HDL-C levels | [56] |
Bile-acid sequestrants | ↑ TG levels | [1, 64-66] |
Fibrates | ↑ LDL-C levels (in patients with hypertriglyceridemia) | [1, 67] |
Omega-3 fatty acids | ↑ LDL-C levels (in patients with severe hypertriglyceridemia) | [68-70] |