Table 2: Niacin Action on Cytokine Production by Macrophages from Mice Injected with LPS
Treatment
Cytokines levels (pg/ml)
IL-1β
TNF-α
IL-6
PBS
Non detectable
23 ± 14
35± 18
LPS
458 ± 57*
856 ± 101*
934 ± 123*
PBS + Niacin
Non detectable
19 ± 16
32 ± 25
LPS + Niacin
209 ± 32* #
486 ± 52* #
492 ± 67* #
Control mice were injected with PBS or LPS (20 mg/Kg) and were simultaneously orally treated with or without Niacin (250 mg/Kg). After 12 h, macrophages
were collected and incubated for other 12 h in supplemented medium. Cell free supernatants were obtained to determine cytokine levels as described
in Fig. (4). Data are mean ± S.E.M. of three animals *p<0.05 respect the corresponding PBS injected mice, #p<0.05 respect the corresponding non Niacin
treated mice