Table 2: Niacin Action on Cytokine Production by Macrophages from Mice Injected with LPS

Treatment Cytokines levels (pg/ml)
IL-1β TNF-α IL-6
PBS Non detectable 23 ± 14 35± 18
LPS 458 ± 57* 856 ± 101* 934 ± 123*
PBS + Niacin Non detectable 19 ± 16 32 ± 25
LPS + Niacin 209 ± 32* # 486 ± 52* # 492 ± 67* #

Control mice were injected with PBS or LPS (20 mg/Kg) and were simultaneously orally treated with or without Niacin (250 mg/Kg). After 12 h, macrophages were collected and incubated for other 12 h in supplemented medium. Cell free supernatants were obtained to determine cytokine levels as described in Fig. (4). Data are mean ± S.E.M. of three animals *p<0.05 respect the corresponding PBS injected mice, #p<0.05 respect the corresponding non Niacin treated mice