Table 1: List of included studies.

Study ;
Type of Study:
Participants Intervention Control Outcome
Outcome measure used Numerical values
Intervention Group Control Group
Klein et al. [12]
RCT; open label; parallel group
21 children of 3-5 years of age who required pulp tissue removal and subsequent crown/extraction for at least two teeth in the anterior maxillary segment on opposite sides of the midline P-ASA with CompuMed- 1.4 ml of 2% lignocaine with 1:100,000 epinephrine Several buccal infiltrations and an additional palatal injection- Traditional syringe- 2% lignocaine with 1:100,000 epinephrine in 1.8ml cartridge with a 30-gauge needle Disruptive behaviour using anxious and disruptive behaviour code 50% disruptive behaviour,
30% crying and
28% body movement were observed
75% disruptive behaviour,
57% crying and
49% body movement were observed
Loomer PM et al. [13]
RCT, single blind, cross over design
20 adults with moderate periodontal disease requiring scaling and root planning AMSA and P-ASA using 2% lignocaine with 1:100,000epinephrine. PSA,MSA,ASA,GP,NP using 2% lignocaine in 1:100,000 epinephrine Visual analog scale (VAS) A mean (SD) difference of 0.19 (0.24) was observed in VAS from baseline A mean (SD) difference of 0.22 (0.24) was observed in VAS from baseline
Yenisey M [14]
RCT, single blinded study using split mouth design
16 adult patients aged 27 to 64 years, with partially edentulous state in both right and left maxilla to undergo fixed prosthodontics treatment AMSA using Wand at 1.7 ml articaine hydrochloride with 0.006 mg adrenaline using 27 G needle 2 ml articaine hydrochloride with 0.006 mg adrenaline with 27 G needle with a plastic syringe Verbal rating scale (VRS) Median (range) of VRS was 0 (0-2) Median (range) of VRS was 2 (0-3)
Tahmassebi et al. [15]
RCT; single blinded; parallel group
38 children of age 39-120 months in need of at least one restoration on either side of maxilla Wand assisted buccal infiltration and direct palatal injection of 2% lignocaine in 1:80000 adrenaline Buccal and intra papillary infiltration using 2% lignocaine in 1:80000 adrenaline The anxiety using Venham scale and
modified VAS for pain
Mean (SD) of anxiety score - 1.7 (2.5) and 32.1 (30.8) for VAS Mean (SD) of anxiety score -
1.5 (1.9) and 29.4 (22.4) for VAS
Kandiah et al. [16]
RCT; single blinded; parallel group
30 individuals of 8-16 years with minimal caries requiring restoration of upper first permanent molar tooth Wand assisted infiltration using 1.8 ml of 2% lignocaine in 1:80000 adrenaline Traditional syringe assisted infiltration of 1.8 ml of 2% lignocaine in 1:80000 adrenaline Onset of anaesthesia measured by Electric pulp testing;
Pain measured by modified visual analog scale
Mean (SD)
of onset of anaesthesia was 6.8 (3.1)
and 14/15 had no pain
Mean (SD) of onset of anaesthesia was 6.1 (2.7) and 12/14 had no pain
Allen et al. [17]
RCT; single blinded; parallel group
40 patients 2-5 years of age needing operative dentistry in maxilla Wand assisted AMSA or P-ASA of 1.4 ml 2% lignocaine with 1:100000 epinephrine using 30 G needle Traditional 1 ml buccal infiltration and 0.18 ml palatal injection of 2% lignocaine with 1:100000 epinephrine using 30 G needle Any disruptive behaviour; Crying; Body movement and restraint 50% had disruptive behaviour; 30% had crying spells; 28% had body movement and 3% restraint 71% had disruptive behaviour; 57% had crying spells; 49% had body movement and 34% restraint

Risk of bias of the included studies in the systematic review.