The Open Dentistry Journal




ISSN: 1874-2106 ― Volume 13, 2019

Lipoma of the Palate: An Uncommon Finding



Luiz Evaristo Ricci Volpato1, 2, *, Artur Cunha Vasconcelos2, Nayane Assis Lambert2, Paulo Henrique de Souza Castro2, Arlindo Aburad2, Alvaro Henrique Borges1
1 University of Cuiabá, Cuiabá Dental School, Cuiabá, MT Brazil
2 Mato Grosso Cancer Hospital, Dentistry Department, Cuiabá, MT, Brazil

Abstract

Background:

Lipoma is a benign neoplasm originated from adipose cells circumscribed by connective tissue. This neoplasm represents about 1% to 4.4% of all oral benign tumors and it is rarely located in the palate area.

Objective:

This case reports the occurrence of an oral lipoma in the hard palate of a 57-year-old woman and discusses its etiology and treatment.

Case Report:

The treatment consisted in the total resection of the lesion and laser therapy. The patient is being followed up for forty three months with no signs of recurrence.

Conclusion:

Lipoma in hard palate is a rare entity that may be associated with endocrine factors and local inflammation.

Keywords: Adipocytes, Benign Neoplasm, Lipoma, Mature Fat Cells, Mesenchymal Neoplasm.


Article Information


Identifiers and Pagination:

Year: 2016
Volume: 10
First Page: 643
Last Page: 646
Publisher Id: TODENTJ-10-643
DOI: 10.2174/1874210601610010643

Article History:

Received Date: 30/05/2016
Revision Received Date: 21/09/2016
Acceptance Date: 27/10/2016
Electronic publication date: 29/11/2016
Collection year: 2016

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open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution-Non-Commercial 4.0 International Public License (CC BY-NC 4.0) (https://creativecommons.org/licenses/by-nc/4.0/legalcode), which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.


* Address correspondence to this author at the R. Alm. Henrique Pinheiro Guedes, 303 - Duque de Caxias, Cuiabá, MT, Brazil; Fax: 55 65 3622-0083; E-mail: odontologiavolpato@uol.com.br




INTRODUCTION

Lipoma is a benign mesenchymal tumor constituted by encapsulated mature adipose tissue with variably sized adipocytes [1Furlong MA, Fanburg-Smith JC, Childers ELB. Lipoma of the oral and maxillofacial region: Site and subclassification of 125 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endodontol 2004; 98: 441-50.
[http://dx.doi.org/10.1016/S1079210404001805] [PMID: 15472660]
]. Clinically, it is characterized as a painless well delimited nodular mass with yellow surfaces located mainly in the back, neck, chest wall, face, and femur [2Taira Y, Yasukawa K, Yamamori I, Iino M. Oral lipoma extending superiorly from mandibular gingivobuccal fold to gingiva: a case report and analysis of 207 patients with oral lipoma in Japan. Odontology 2012; 100: 104-8.
[http://dx.doi.org/10.1007/s10266-011-0027-0] [PMID: 21607594]
].

When at the oral cavity, lipomas are majorly located in this order: tongue; floor of mouth; buccal vestibule; lip; palate; gingiva and retromolar region [3Christy W, Bojan A, Mathew B, Shanmugam S. Lipoma in the Palate: A Rare Presentation. J Ind Acad Oral Med Radiol 2010; 22: S51-2.].

The case of a lipoma located in the hard palate is presented, highlighting its clinical and imaginological aspects, therapeutics and follow up.

CASE REPORT

A 57-year-old woman attended the Mato Grosso Cancer Hospital referred by a general dentist to evaluate and treat a lesion on hard palate impeding her to use the upper denture. She reported having Diabetes Mellitus type 2, in use of metformin hydrochloride 850 mg and denied any drug allergy.

The clinical assessment revealed a normal colored volumetric tissue increase with fibrous consistence and smooth surface of approximately 30 mm of diameter located on the right side of the hard palate with one year of evolution (Fig. 1).

Fig. (1)
Clinical aspect showing a normal colored volumetric tissue increase with fibrous consistence and smooth surface of approximately 30 mm of diameter located on the right side of the hard palate.


The computed tomography, in axial cut, showed a hypodense area in the right side of the hard palate, corroborating to the diagnostic hypothesis (Fig. 2).

Fig. (2)
Computed tomography, in different cuts, showing a hypodense area in the right side of the hard palate (arrows). Pneumatization of the maxillary bone can be seen as a large radiolucency on the left side of the maxilla.


Excisional biopsy of lesion was performed. Histological examination of the excised specimen revealed a mucosal fragment covered by parakeratinized stratified squamous epithelium and skin basement membrane formed by fibrous connective tissue (Fig. 3). In the submucosa, proliferation of mature adipose cells was noted, leading to the diagnosis of lipoma.

Fig. (3)
Histological aspect showing a parakeratinized stratified squamous epithelium, lamina propria formed by fibrous connective tissue and proliferation of mature adipose cells in the submucosa.


After biopsy, low level laser therapy was performed aiming to improve wound healing. The protocol used was punctual application around the operated area, as follows: four points with red laser (wavelength of 660 nm ± 10 nm) and four points with infra-red laser (wavelength of 808 nm ± 10 nm), 40 seconds per point, totalizing the fluence of 4J/cm2 with a proper device (XT Therapy – DMC, São Paulo, Brazil). This protocol was executed in 14 sessions (3 times/week).

The patient was followed up for forty three months without recurrence (Fig. 4).

Fig. (4)
Clinical aspect of the hard palate after forty three months of follow up showing complete healing end no sign of recurrence of the lesion.


DISCUSSION

Lipoma is a benign tumor that arises of mature adipose cells in the mesenchymal tissue and because of their abundance it can occur in several soft tissues as retroperitoneum, and the omentum. However, in the head and neck region it is a lesion extremely rare reported in hypopharynx, larynx, oral cavity, nasopharynx, and the retropharyngeal space. As there is little adipose tissue in the hard palate, it is not often its emergence at that site [3Christy W, Bojan A, Mathew B, Shanmugam S. Lipoma in the Palate: A Rare Presentation. J Ind Acad Oral Med Radiol 2010; 22: S51-2., 4SY A, Nao EEM, Ndiaye M, Taddio JM, Pegbessou EP, Ndiaye C. Lipoma of the soft palate: A rare anatomo clinicalentity. Euro Annals Otorhinolaryngol Head Neck Dis 2010; 127: 151-2.
[http://dx.doi.org/10.1016/j.anorl.2010.05.001] [PMID: 20860925]
] as occurred in this case.

In the presented case the lesion had a pink coloring aspect. However it is common for lipomas to exhibit yellow color, characteristic of adipose tissue and visible through the thin overlying epithelium [3Christy W, Bojan A, Mathew B, Shanmugam S. Lipoma in the Palate: A Rare Presentation. J Ind Acad Oral Med Radiol 2010; 22: S51-2.]. Clinically, differential diagnosis of lipomas include dermoid cysts, ranulae, thyroglossal duct cysts, pleomorphic adenomas, ectopic thyroid tissues, mucoepidermoid carcinomas, angiolipomas, fibrolipomas and malignant lymphomas [5Ravi KA, Purnachandrarao NN, Samatha Y, Vijay KA, Kalyan KD. Intraoral lipoma: A rare case report and review of literature. J Clin Diagnos Res 2013; 12: 3090-1.
[http://dx.doi.org/10.7860/JCDR/2013/6845.3863] [PMID: 24551738]
].

Patient was 57 years old. Typical lipoma occurs in patients most often between the ages of 40 and 60 years and it is uncommon for pediatric patients [1Furlong MA, Fanburg-Smith JC, Childers ELB. Lipoma of the oral and maxillofacial region: Site and subclassification of 125 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endodontol 2004; 98: 441-50.
[http://dx.doi.org/10.1016/S1079210404001805] [PMID: 15472660]
, 2Taira Y, Yasukawa K, Yamamori I, Iino M. Oral lipoma extending superiorly from mandibular gingivobuccal fold to gingiva: a case report and analysis of 207 patients with oral lipoma in Japan. Odontology 2012; 100: 104-8.
[http://dx.doi.org/10.1007/s10266-011-0027-0] [PMID: 21607594]
].

The ultrasound and magnetic resonance imaging can be used to differentiate infiltrating lipoma from well-limited lipoma that shows hypodense homogenous mass [4SY A, Nao EEM, Ndiaye M, Taddio JM, Pegbessou EP, Ndiaye C. Lipoma of the soft palate: A rare anatomo clinicalentity. Euro Annals Otorhinolaryngol Head Neck Dis 2010; 127: 151-2.
[http://dx.doi.org/10.1016/j.anorl.2010.05.001] [PMID: 20860925]
]. In the presented case, radiograph and CT were necessary to establish the lesion limits, guiding the complete surgical resection of the lesion.

After the resection of the lesion, the wound site was treated with laser therapy to improve wound healing and post-operative comfort. The application of low level laser is known to promote tissue regeneration, reduce inflammation and relieve pain in a healing area [6Farivar S, Malekshahabi T, Shiari R. Biological effects of low level laser therapy. J Lasers Med Sci 2014; 18(5): 58-62.
[PMID: 25653800]
]. The recurrence of lipoma is unlikely when there is the resection of entire encapsulated lesions but its follow up is necessary because of the possibility of transformation into a malign lesion [2Taira Y, Yasukawa K, Yamamori I, Iino M. Oral lipoma extending superiorly from mandibular gingivobuccal fold to gingiva: a case report and analysis of 207 patients with oral lipoma in Japan. Odontology 2012; 100: 104-8.
[http://dx.doi.org/10.1007/s10266-011-0027-0] [PMID: 21607594]
]. In the present case, after for forty three months of follow up there is no sign of recurrence of the lesion.

CONFLICT OF INTEREST

The authors confirm that this article content has no conflict of interest.

ACKNOWLEDGEMENTS

Declared none.

REFERENCES

[1] Furlong MA, Fanburg-Smith JC, Childers ELB. Lipoma of the oral and maxillofacial region: Site and subclassification of 125 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endodontol 2004; 98: 441-50.
[http://dx.doi.org/10.1016/S1079210404001805] [PMID: 15472660]
[2] Taira Y, Yasukawa K, Yamamori I, Iino M. Oral lipoma extending superiorly from mandibular gingivobuccal fold to gingiva: a case report and analysis of 207 patients with oral lipoma in Japan. Odontology 2012; 100: 104-8.
[http://dx.doi.org/10.1007/s10266-011-0027-0] [PMID: 21607594]
[3] Christy W, Bojan A, Mathew B, Shanmugam S. Lipoma in the Palate: A Rare Presentation. J Ind Acad Oral Med Radiol 2010; 22: S51-2.
[4] SY A, Nao EEM, Ndiaye M, Taddio JM, Pegbessou EP, Ndiaye C. Lipoma of the soft palate: A rare anatomo clinicalentity. Euro Annals Otorhinolaryngol Head Neck Dis 2010; 127: 151-2.
[http://dx.doi.org/10.1016/j.anorl.2010.05.001] [PMID: 20860925]
[5] Ravi KA, Purnachandrarao NN, Samatha Y, Vijay KA, Kalyan KD. Intraoral lipoma: A rare case report and review of literature. J Clin Diagnos Res 2013; 12: 3090-1.
[http://dx.doi.org/10.7860/JCDR/2013/6845.3863] [PMID: 24551738]
[6] Farivar S, Malekshahabi T, Shiari R. Biological effects of low level laser therapy. J Lasers Med Sci 2014; 18(5): 58-62.
[PMID: 25653800]

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