Table 1: Key characteristics of the included studies.

Author Participants Intervention Control Outcome
Jena A
20138
100 Adult patients requiring endodontic treatment for tooth diagnosed with irreversible pulpitis 20 patients-Oral ketorolac 10mg pre-medication after which conventional inferior alveolar nerve block will be administered. 20 patients-placebo with sugar coated pills
20 patients-ibuprofen 600 mg
20 patients-etodolac with paracetamol(400mg+500mg)
20 patients-aceclofenac with paracetamol(100mg+500mg)
After all the above mentioned control, conventional inferior alveolar nerve block will be administered.
Visual analog scale
Overall success of inferior alveolar nerve block
Ganguly SA
20169
126 adult patients requiring endodontic treatment for tooth diagnosed with irreversible pulpitis 42 patients- ketorolac pre-medication after which conventional inferior alveolar nerve block will be administered 42 patients- diclofenac potassium
42 patients- Placebo
After all the above mentioned control, conventional inferior alveolar nerve block will be administered.
Visual analog scale
Overall success of inferior alveolar nerve block
Aggarwal V
201010
62 adult patients requiring endodontic treatment for tooth diagnosed with irreversible pulpitis 24 patients- ketorolac 10mg pre-medication after which conventional inferior alveolar nerve block will be administered 24 patients- ibuprofen 300mg
24 patients- placebo
After all the above mentioned control, conventional inferior alveolar nerve block will be administered.
Visual analog scale
Overall success of inferior alveolar nerve block
Yadav M
201511
50 adult patients requiring endodontic treatment for tooth diagnosed with irreversible pulpitis 25 patients -ketorolac 10mg pre-medication after which conventional inferior alveolar nerve block will be administered after buccal and lingual infiltrations. 25 patients- no pre-medication. Conventional inferior alveolar nerve block will be administered after buccal and lingual infiltrations. Overall success of inferior alveolar nerve block