Is Conservative Surgery the Best Approach for Peripheral Calcifying Epithelial Odontogenic Tumors?

Table 1: Previous articles about peripheral calcifying epithelial odontogenic tumor including clear cell variant with emphasis in the treatment.

Authors	Anatomic Site	Duration	Clinical Presentation	Imaging Presentation	Treatment	Recurrence	Folow-up
Pindborg, 1966⁵	Max. gingiva	5 years	Painless firm mass	NCI	Simple excision	No	NCI
Abrams and Howell, 1967¹⁰**	Mand. gingiva	NA	Painless firm mass	Crest resorption	Simple excision	No	3 years
Decker and Laffitte, 1967¹¹	Mand. gingiva	5years	Painless firm mass	NCI	Simple excision	No	NCI
Patterson et al, 1969¹²	Mand. gingiva	1 year	Painless firm mass	NCI	Simple excision	No	NCI
Krolls and Pindborg, 1974¹³	Mand. gingiva	NA	Painless firm mass	NCI	Simple excision	No	NCI
Wherteimer et al., 1977¹⁴**	Max. gingiva	NA	Painless firm mass	No	Simple excision	No	NA
Ai-ru et al., 1982¹⁵**	Mand. gingiva	10 years	Painless firm mass	NCI	Ressection	No	2 years
Ai-ru et al., 1982¹⁵**	Mand. gingiva	2 years	Painless firm mass	No	Partial ressection	No	10 years
Takeda et al., 1983¹⁶	Max gingiva	NA	Painless firm mass	NCI	Excision underlying bone	No	NCI
KH Ng et al., 1996¹⁷	Max. gingiva	1 year	Painless firm swelling	Erosion	Excision	No	NA
Houston & Fowler, 1997¹⁸**	Max. gingiva	5 months	Ulcerated mass	No	Simple excision	No	4 years
Houston & Fowler, 1997¹⁸**	Mand. gingiva	5 months	Ulcerated mass	Erosion*	Simple excision	No	4 years
Orsini et al., 2000⁹**	Max. gingiva	6 months	Painless red mass	Not performed	Simple excision	No	4 years
Mesquita et al., 2003⁶**	Max. gingiva	10 months	Painless firm nodule	No	Excision	No	2.5 years
de Oliveira et al., 2009²**	Max. gingiva	NA	Painless exophitic mass	No	Excision	No	1 year
de Oliveira et al., 2009²**	Mand. gingiva	NA	Painless exophitic mass	Superficial cupping	Excision	No	1 year
Abrahão et al., 2009^19b	Mand gingiva	3 months	Painfull erithematous swelling	No^a	Simple excision^c	Yes^d	3.5 years
Habibi et al., 2009²⁰**	Max. gingiva	11 years	Ulcerated mass	NCI	Excisional biopsy with 5-mm safety margins	No	NA
Marino et al., 2013²¹	Max. gingiva	NA	Painless swelling	Bone resorption	Conservative surgery including teeth extraction	No	2 years
Afrogheh et al., 2014⁷**	Mand. gingiva	6 months	Painless swelling	Erosion	Complete excision	No	1.5 years
Shetty et al., 2016²²**	Mand. gingiva	8 months	Painless swelling	No	Excisional biopsy	No	6 months
de Carvalho et al., 2016²⁶	Mand. gingiva	1 month	Painless swelling	No	Excisional biopsy	No	1 year
Bajpai M, 2018²³**	Max. gingiva	9 months	Pink-coloured swelling	Loss of lamina dura	Complete excision	No	6 months
Flores et al., 2018**¡	Mand. gingiva	4 years	Painless swelling	Superficial hypodense cupping	Conservative surgery	No	22 months

Max.= maxillary Mand. = mandible NA = Not available NCI = Not clearly identified a = osseous resorption and calcifications (recurrent lesions) b = bilateral c = soft tissue excision followed bone curettage d = after 1 year *Observed only during the surgical procedure **Clear cell variant ¡ Current case