| Author |
Study Design Number of Cases |
Time of Examination | Sex | Age | History of Perio | Smoking |
Jaw: Max./ Mand./ Both |
Location: Inc/PM/M | Reason for Extraction | Socket Classification |
|---|---|---|---|---|---|---|---|---|---|---|
| Barone et al. (2008) | RCT / 40 | 7–9 months | 16 male, 24 female |
26–69 y | Not described | Heavy smokers (> 10 cig/d) excluded |
both | Inc/PM | Not described | Only alveoli with 4 intact walls |
| Barone et al. (2017) | RCT / 90 | 3 months | 36 male, 54 female |
25–70 y, mean 47.4 y | Not described | Heavy smokers (> 10 cig/d) excluded | both | PM/M | Decay, endodontic failure, fracture | Y, according to Juodzbalys (2008) |
| Cardaropoli et al. (2012) |
RCT / 48 | 4 months | 24 male, 17 female |
24–71 Y, mean 47.2 y | Acute perio excluded | Heavy smokers (> 10 cig/d) excluded | both | PM/M | root fracture, periodontal involvement, endodontic treatment failure. decay | three intact walls and at least 80% of the fourth wall intact |
| Casado et al. (2010) | CT / 15. no histology in the control group |
4 months | No data | No data | Not described | Not described | both | Inc/PM/M | Not described | Intact alveoli only |
| De Coster et al. (2011) |
CT / 10 (23 sockets) | 6–74 weeks | 8 male, 2 female |
41-81 y | Not described | Smokers and non-smokers | both | Inc/PM/M | Caries, perio, fracture | Intact buccal bone |
| Crespi et al. (2009) | RCT / 45 | 3 months | 8 male, 7 female |
28–-71 y, mean 51.3 y | Excluded | Non-smokers | both | PM/M | Not described | 3-walled, loss of the buccal bone wall |
| Nahles et al. (2013) | RCT / 33 | 25 sites: 4 weeks, 40 sites: 12 weeks |
18 male, 15 female |
30–73 y, mean 54.5 y | Acute PAR and with PPD > 5 mm excluded | Non-smokers | both | Inc/PM/M | Not described | 4 walls |
| Pelegrine et al. (2010) |
CT / 13 | 6 months | 7 male, 6 female |
28–70 y, mean 47.5 y |
Not described | Non-smokers | OK | Inc | Not described | Not described |
| Barone et al. (2008) | Y | AB (4 days); CHX rinse (3 weeks) | Xenogeneic | Corticocancellous porcine bone | MP3; OsteoBiol, Coazze, Italy | Test group: Y; control group: N | Evolution collagen membrane; OsteoBiol, Coazze, Italy | Yes, more trabecular bone and less connective tissue in the test group | ||
| Barone et al. (2017) | N | AB (5 days), CHX rinse (3 weeks) | Xenogeneic | Test 1: collagenated cortico-cancellous porcine bone; test 2: cortical porcine bone | Test 1: MP3;OsteoBiol, Coazze, Italy, Test 2: Apatos; OsteoBiol, Coazze, Italy |
Test group: Y; control group: N | Evolution collagen membrane; OsteoBiol, Coazze, Italy | Yes, greater mineralization in the cortical-bone test group | ||
| Cardaropoli et al. (2012) | N | AB (6 days); + CHX rinse (duration not stated) | Xenoeneic | Bovine bone mineral | Bio-Oss Collagen | Y | Only test group with porcine collagen membrane (Bio-Gide) | Yes, more new bone in test group | ||
| De Coster et al. (2011) |
Y | Not described | Alloplastic | 60% hydroxyapatite, 40% β-tricalcium phosphate |
BoneCeramic (Straumann AG) | Y | Primary wound closure, no membrane | Not reported | ||
| Crespi et al. (2009) | N | Single shot of Amoxicillin 1 g, 1 h pre-op | Alloplastic | 15 magnesium-enriched hydroxyapatite (MHA), 15 calcium sulfate (CS) | MHA: SINTlife; Finceramica, Faenza, Italy; CS: Easy Set; Sweden-Matina, Due Carrare, Italy | Y | Y, with collagen membrane | Yes, with vital bone and connective tissue | ||
| Nahles et al. (2013) | N | Not described | Xenogeneic | Bovine granules and porcine collagen | Bio-Oss Collagen | N | N | No significant differences at the histomorphometric level | ||
| Pelegrine et al. (2010) |
Y | Not described | Autologous | Iliac crest bone marrow | N/A | Y | Sutured after periosteal slit | No, no significant differences |