Fig (4a) Histological section of healthy palatal mucosa (CHM). E-cadherin was detected by immunoperoxydase technique on the first srata of the epithelium. (b) Histological section of palatal mucosa of DRS shows the immunolocalisation of E-cadherin with strong staining in all of the epithelium. Connective tissue Infiltrate and basement membrane no clear. (c) Enlargement showing mild dysplasia of the epithelium with widening of space between keratinocytes.