Bisphosphonate-Associated Osteonecrosis of the Jaw: Are We Dealing with a Localized Non-Traditional Calciphylaxis?

Fig. (1) ONJ cases with adjacent soft tissue were stained for calcium using von Kossa. A, B: ONJ staining for calcium positive in 8 of 10 cases around vessels and in the connective tissue (black/brown). C: Bone showing calcium staining at the leading edge. D: Normal oral mucosa control (A, C, D 400x/ B 200X).