Drug and Therapy | Mechanisms of Action | Adverse Events |
---|---|---|
Insulin and its derivatives | Glucose metabolisms | Not significance |
Sulphonylurea | Stimulate insulin secretions | Gastrointestinal (20-30%) Infections (20%) |
Biguanide (Metforrnin) | Decrease amount of sugar productions by liver | Metabolisms |
Acarbose Voglibose |
α-glucosidase inhibitors | Gastrointestinal (20-30%) |
Pioglitazone | Receptor agonists | Heart failure (1-5%) Bladder carcinoma (1-2%) |
Exercise | Mimics insulin actions | Not significance |
Curcumin Resveratol |
Plant chemicals Wider biochemical pathways |
Low |
Other melbine | Variable | Variability |
α-thioctic acids (Lipoic acid) | Disease complications | Not obvious |
New anti-diabetic drugs | SGLT-2 inhibition DPP4 antagonists |
Under investigations |