Fig. (1) IO HAT study design. Severe hypoglycemia: an event requiring assistance of another person to actively administer carbohydrate, glucagon, or other resuscitative actions. Non-severe hypoglycemia: documented symptomatic (symptoms and blood glucose measurement ≤3.9 mmol/L [70 mg/dL]) and probable symptomatic (symptoms only) hypoglycemia. NSH, Non-Severe Hypoglycemia; SAQ: Self-Assessment Questionnaire; SH: Severe Hypoglycemia.