Table 2:
Comparison of 6β -Hydroxycortisol and 6β-Hydroxycortisol-to-Free-Cortisol Ratio in all 24 Subjects During Gepirone Treatment, with or without Concurrent Rifampin (600 mg/day)
Without Rifampin
With Rifampin
P
-Value
Day 1
Day 7
Day 1
Day 7
6b-hydroxycortisol (µg)
197 ± 117
178 ± 75
181 ± 75.6
786 ± 366
< .001
a
6b-hydroxycortisol-to-free-cortisol ratio
4.5 ± 2.0
4.0 ± 1.5
4.6 ± 2.5
21.4± 8.4
< .001
a
a
Gepirone alone (study period A) versus gepirone with rifampin (study period B).