Fig. (4) Comparison of steroids behaviour towards CYP1A enzymes. (A) The MDS model used was ratio (stress = 0.167). Each point represents a particular steroid (solid circle) or steroid analogue (triangles) substrate. RU and RU NdM stand, respectively, for total RU486 hydroxylase activity and RU486 N-demethylase activity. cA, cis-androsterone; tA, trans-androsterone; DHEA, dehydroepiandrosterone; NA, 19-norandrostenedione; PREG, pregnenolone; PROG, progesterone; HC, hydrocortisone; 21oh, 21-hydroxyprogesterone; 17oh, 17- hydroxyprogesterone; CC, corticosterone; NK, nootkatone; T, testosterone; CX, cortexolone; MT, 17-methyl-testosterone; and EST, estrone.