Differences in Functional Clustering of Endogenous and Exogenous Substrates Between Members of the CYP1A Subfamily

Table 1: CYP1A Enzyme Similarity for Global Metabolisms of Steroid and PAH Substrates

	Human CYP1A1	Human CYP1A2	Mouse CYP1A1	Rabbit CYP1A2
Human CYP1A1
Human CYP1A2	1 / 2
Mouse CYP1A1	76 / 65	13 / 21
Rabbit CYP1A2	29 / 9	8 / 95	54 / 25	100 /100

For each two CYP1A enzymes compared, the left number is the percentage of similarity for steroid activities measured from their distance in the MDS plot, and the right number is the percentage of similarity for PAH activities. The 100 % was set from the average within-cluster distances measured with duplicate assays.