Table 7: Means of In Vivo Clearance, Volume of Distribution, % Plasma Protein Binding, LogP and PSA. Groups were Classified
Based on the Correlation Between In Vivo CL and Predicted CLin vitro Calculated from Model A
Group |
In VivoCL (ml/min/kg) |
VSS (L/kg) |
% Plasma Protein Binding |
LogP |
PSA |
%Remaining |
Good prediction |
26.18 ± 22.62 |
3.52 ± 6.02 |
77.96 ± 32.75 |
3.39 ± 1.61 |
102 ± 32 |
80.47 ± 13.90 |
Under prediction |
49.18 ± 27.26 |
4.61± 6.32 |
85.95 ± 63.39 |
3.10 ± 1.73 |
99.22 ± 33.49 |
88.90 ± 9.65 |
Over prediction |
6.88 ± 4.76 |
1.35 ± 1.35 |
74.77± 30.61 |
3.41 ± 1.62 |
90.46 ± 33.48 |
76.54 ± 14.57 |