Table 7: Means of In Vivo Clearance, Volume of Distribution, % Plasma Protein Binding, LogP and PSA. Groups were Classified Based on the Correlation Between In Vivo CL and Predicted CLin vitro Calculated from Model A

Group In VivoCL (ml/min/kg) VSS (L/kg) % Plasma Protein Binding LogP PSA %Remaining
Good prediction 26.18 ± 22.62 3.52 ± 6.02 77.96 ± 32.75 3.39 ± 1.61 102 ± 32 80.47 ± 13.90
Under prediction 49.18 ± 27.26 4.61± 6.32 85.95 ± 63.39 3.10 ± 1.73 99.22 ± 33.49 88.90 ± 9.65
Over prediction 6.88 ± 4.76 1.35 ± 1.35 74.77± 30.61 3.41 ± 1.62 90.46 ± 33.48 76.54 ± 14.57

Note: Mean ± SD, N=146.