Fig. (2) Hyaluronan serum levels with dose-escalation. HA levels were determined following injection of escalating doses of HA [1.5 mg/kg (period 1), 3 mg/kg (period 2), 6 mg/kg (period 3), and 12 mg/kg (period 4)], administered as an i.v. infusion over 2 h. All values have been corrected for baseline, endogenous serum HA levels. Values represent the mean of n=24 for the 1.5, 3.0, and 6.0 mg/kg doses and n=23 for the 12 mg/kg dose. Lines are obtained from least-squares fitting of the mean data for each set to the pharmacokinetic model (Fig. 1).