Fig. (3) Total FITC-HA binding to CD14+ PBMC for each
dosing period.The binding of FITC-HA to CD14+ PBMC (monocytes)
was quantified by FACS and total binding was calculated by
measuring AUC as described in Subjects, Materials and Methods.
Values represent the mean of samples from 6 volunteers ± SE.
AUC was significantly greater in the 4th dosing period when compared
to periods 1-3 (P<0.0001).