Pharmacokinetics and Pharmacodynamics of Hyaluronan Infused into Healthy Human Volunteers

Table 3: Frequency of Adverse Effects

Adverse Effects	Frequency	Related to Study	Severity	Subject Continued or Discontinued in Study
Influenza	1	Unrelated	Mild	Discontinued
Lower Arm Rash	1	Possibly related	Mild	Continued
Headache	4	Possibly related	Mild	Continued
Pro-thrombin Time	2	^aUnrelated	Mild	Continued
Practical Thromboplastic Time	2	^aUnrelated	Mild	Continued
Others	7	Possibly related	Mild	Continued

^a See Methods and Results sections for descriptions of procedures.Levels were altered at normal, endogenous HA levels.