Table 4: Baseline Corrected Hyaluronan Mean Concentration (Cp), ng/mL

Time (hr) 1.5 mg/kg Mean [+/-SD] N=24 3.0 mg/kg Mean [+/-SD] N=24 6.0 mg/kg Mean [+/-SD] N=24 12.0 mg/kg Mean [+/-SD] N=23
Infusion Period 0a 0
[0]
0
[0]
0
[0]
0
[0]
0.5a 7761
[1130]
17713
[3021]
38838
[6162]
77186
[11297]
1a 15280
[2783]
34625
[5621]
84083
[13648]
154713
[26503]
1.5a 24052
[3653]
52052
[9039]
129204
[16063]
254994
[40017]
2a 26284
[3918]
63063
[16099]
131549
[17324]
313554
[41271]
4 14419
[3384]
52167
[7646]
121122
[13000]
325913
[51980]
6 4633
[3518]
36334
[6390]
104426
[16384]
264232
[40440]
10 40
[56]
12934
[7139]
73627
[12514]
21550
[28998]
14 24
[12]
1755
[3188]
50440
[13547]
195145
[32153]
18 33
[19]
61
[103]
26522
[13128]
153467
[22857]
22 35
[7]
23
[14]
10769
[12496]
146773
[27505]
26 24
[16]
19
[10]
1839
[4367]
94579
[31429]
32 22
[17]
7
[4]
28
[55]
54615
[29332]
38 18
[10]
23
[14]
16
[11]
21795
[21939]
50 22
[14]
29
[10]
16
[11]
419
[1373]
74 31
[12]
15
[10]
22
[16]
15
[7]

a The infusion period was 0-4 hrs.