Pharmacokinetics and Pharmacodynamics of Hyaluronan Infused into Healthy Human Volunteers

Table 5: Hyaluronan Pharmacokinetics

Dose	C_max (mg/mL)	AUC_{0-75 h,} (mg/hr/mL)	k_syn^a (mg/hr/kg)	V_max^a (mg/hr/kg)	K_m^a (mg/mL)	V_max/K_m (mL/hr/kg)	V_d^a (mL/kg)
1.5 mg/kg	26 ± 4	103	29 ± 1.1	340 ± 34	6.4 ± 2.1	53.4	38.3 ± 0.9
3.0 mg/kg	63 ± 16	407	1.3 ± 0.4	348 ± 13	11.8 ± 1.3	29.5	38.4 ± 0.4
6.0 mg/kg	131 ± 17	1503	0.9 ± 0.4	334 ± 16	14.6 ± 2.7	22.9	38.4 ± 0.4
12.0 mg/kg	314 ± 41	5930	0.6 ± 0.4	371 ± 11	26.5 ± 3.4	14	36.7 ± 0.8

See Methods and Results sections for descriptions of calculation of C_max and plasma concentration of AUC_{0-75 h} (area-under-concentration curve from 0 to 75 h) and ^aEstimated value ± S.D. using model-dependent analysis.