Pharmacokinetics and Pharmacodynamics of Hyaluronan Infused into Healthy Human Volunteers

Table 6: Peak HA Binding^a by T (CD4+, CD8+) and B (CD19+) Cells in Response to Escalating Doses of HA

	Period 1			Period 2			Period 3			Period 4
hours	CD4+	CD8+	CD19+	CD4+	CD8+	CD19+	CD4+	CD8+	CD19+	CD4+	CD8+	CD19+
0.5	20	18	50	10	10	80	8	8	30	10	10	10
2	25	20	70	12	13	95	10	12	100	20	20	50
14	35	30	90	8	8	50	8	8	90	25	15	60
26	5	5	75	10	10	60	8	8	80	25	20	35
74	5	5	40	10	10	40	8	8	80	20	20	40

^a HA binding values have been adjusted for background binding (= 2 units).