Table 1: Model Predicted Hemodynamic Variables in Rats Treated with DTZ
| PK/PD Parameters |
DTZ (5 mg/kg) Bid for 5 Doses |
DTZ (20 mg/kg) Single Dose |
Differences |
| HR Emax |
466 ± 17 bpm |
448 ± 11 bpm |
P > 0.05 |
| HR Emin |
339 ± 50
bpm |
379 ± 11
bpm |
P > 0.05 |
| HR EC50 |
1124 ±
436 ng/ml |
908 ± 523
ng/ml |
P > 0.05 |
| HR Emax -Emin |
127 ± 40
bpm |
69 ± 13
bpm |
P > 0.05 |
| SBP Emax |
150 ± 11
mmHg |
139 ± 3.1
mmHg |
P > 0.05 |
| SBP Emin |
72 ± 17
mmHg |
93 ± 18
mmHg |
P > 0.05 |
| SBP EC50 |
1364 ±
634 ng/ml |
2971 ±
144 ng/ml |
P > 0.05 |
| SBP Emax -Emin |
78 ± 17
mmHg |
46 ± 18
mmHg |
P > 0.05 |
| DBP Emax |
120 ± 6
mmHg |
106 ± 3
mmHg |
P > 0.05 |
| DBP Emin |
75 ± 12
mmHg |
54 ± 9
mmHg |
P > 0.05 |
| DBP EC50 |
1039 ±
577 ng/ml |
4682 ±
1874 ng/ml |
P > 0.05 |
| DBP Emax-Emin |
46 ± 12
mmHg |
52 ± 11
mmHg |
P > 0.05 |