| Model Response = aDTZ + constant (20 mg/kg single sc injection) | |||
|---|---|---|---|
| Response/DTZ or Metabolite | HR | SBP | DBP |
| DTZ | -0.00963 (p = 0.000) |
-0.0004982 (p = 0.578) |
-0.00480 (p = 0.000) |
| Model Response = aDTZ + bMA + cM1 + dM2 + constant (20 mg/kg single sc injection) | |||
| Response/DTZ or Metabolite | HR | SBP | DBP |
| DTZ | - 0.00915 (p = 0.015) |
+0.00196 (p = 0.107) |
- 0.00336 (p = 0.004) |
| MA | + 0.0134 (p = 0.769) |
-0.0290 (p = 0.056) |
-0.0102 (p = 0.465) |
| M1 | - 0.0092 (p = 0.547) |
-0.00947 (p = 0.061) |
-0.00779 (p = 0.098) |
| M2 | - 0.0154 (p = 0.370) |
+ 0.0219 (p = 0.000) |
+ 0.000175 (p = 0.973) |
| Regression Model | P = 0.004 | P = 0.000 | P = 0.000 |
| Model Response = aDTZ + constant (5 mg/kg sc bid for 5 doses) | |||
| Response/DTZ or Metabolite | HR | SBP | DBP |
| DTZ | -0.0292 (p =0.215) |
-0.0157 (p = 0.009) |
-0.0167 (p = 0.007) |
| Model Response = aDTZ + bMA + cM1 + dM2 + constant (5 mg/kg sc bid for 5 doses) | |||
| Response/DTZ or Metabolite | HR | SBP | DBP |
| DTZ | +0.0066 (p = 0.890) |
+ 0.00590 (p = 0.622) |
+0.00396 (p = 0.752) |
| MA | -0.0239 (p = 0.540) |
+ 0.00263 (p = 0.787) |
-0.00694 (p = 0.499) |
| M1 | -0.2397 (p = 0.112) |
-0.100 (p = 0.010) |
-0.0891 (p = 0.027) |
| M2 | + 0.0453 (p = 0.167) |
+ 0.00605 (p = 0.458) |
+0.000946 (p = 0.912) |
| Regression Model | P = 0.248 | P = 0.036 | P = 0.064 |