| |
Group A (naïve patients) |
Group B (subjects who were previously treated with antiretroviral agents) |
p value |
|
| No. of patients |
11 |
16 |
n.s. |
|
| Males/females ratio |
8/3 |
12/4 |
n.s. |
|
| Mean age ± SD (years) |
42 ± 18 |
44 ± 21 |
n.s. |
|
| Homosexuals drug addicts |
5/4/2 |
8/6/2 |
n.s. |
|
| No. of patients (%) |
|
|
|
| - with current cigarette smoking |
5 (45.4) |
7 (43.7) |
n.s. |
| - arterial hypertension |
0 |
2 (12.5) |
n.s. |
| - family history of coronary heart disease |
1 (8.3) |
1 (6.2) |
n.s. |
|
| Mean duration of HIV infection ± SD
(years) |
4.7 ± 2.2 |
9.5 ± 4.3 |
0.009 |
|
| No. of patients (%) with AIDS diagnosis |
0 |
3 (18.7) |
n.s. |
|
| Mean CD4 lymphocyte count ± SD (cells/mm3) |
530 ± 211 |
635 ± 299 |
n.s. |
|
| No. of patients (%) with undetectable HIV viral
load (HIV RNA < 50 copies/mL) |
0 |
12 (75) |
0.021 |
|
| Mean HIV RNA ± SD (log10
copies/mL) in patients with detectable HIV viral load |
3.7 ± 1.6 |
2.8 ± 1.2 |
n.s. |
|
| Mean duration of HAART ± SD (months) |
0 |
74 ± 35 |
0.007 |
|
| Mean concentration of total cholesterol ±
SD (mg/dL) |
178 ± 82 |
219 ± 125 |
0.005 |
|
| Mean concentration of LDL cholesterol ± SD
(mg/dL) |
108 ± 59 |
138 ± 78 |
0.017 |
|
| Mean concentration of HDL cholesterol ± SD
(mg/dL) |
46 ± 21 |
53 ± 29 |
n.s. |
|
| Mean concentration of triglycerides ± SD
(mg/dL) |
112 ± 61 |
167 ± 95 |
0.031 |
|
| Mean concentration of glucose ± SD (mg/dL) |
69 ± 25 |
74 ± 28 |
n.s. |
|
| Mean waist circumference ± SD (cm) |
89 ± 41 |
92 ± 44 |
n.s. |
|
| Mean BMI ± SD (Kg/m2) |
23.9 ± 11.2 |
24.4 ± 10.8 |
n.s. |
|
| No. of patients (%) with metabolic syndrome |
0 |
2 (12.5) |
n.s. |
|
| No. of patients (%) |
0 |
8 (50) |
|
| -with lipodystrophy syndrome |
0 |
3 (18.7) |
|
| -lipoatrophy |
0 |
2 (12.5) |
0.021 |
| - mixed form |
0 |
3 (18.7) |
|
|
| Mean 10-year risk of MI ± SD (%) |
4.4 ± 1.9 |
7.3 ± 2.9 |
n.s. |
|
| Mean IMT ± SD (mm) |
|
|
|
| - right common carotid artery |
0.86 ± 0.45 |
1.38 ± 0.64 |
n.s. |
| - left common carotid artery |
0.82 ± 0.47 |
1.59 ± 0.73 |
n.s. |
| - right carotid bifurcation |
0.95 ± 0.56 |
1.42 ± 0.59 |
n.s. |
| - left carotid bifurcation |
1.02 ± 0.51 |
1.44 ± 0.62 |
n.s. |
| - right internal carotid artery |
0.89 ± 0.49 |
1.27 ± 0.55 |
n.s. |
| - left internal carotid artery |
0.92 ± 0.53 |
1.33 ± 0.75 |
n.s. |
|
| No. of patients (%) with carotid plaques |
0 |
7 (43.7) |
0.012 |
n.s., no significant; SD, standard deviation; AIDS, acquired immunodeficiency syndrome; HAART, highly active antiretroviral therapy; LDL, low-density lipoprotein; HDL, highdensity
lipoprotein; BMI, body mass index; MI, myocardial infarction; IMT, intima-media thickness.