Table 7: Comparison of Different Antiepileptic Drugs’ Uses in the Two Study Periods: 1980-1989 and 1990-1996
| Monotherapy |
1980 – 1989 |
1990 – 1996 |
Total |
| Controls |
Cases |
Controls |
Cases |
Controls |
Cases |
| No. |
% |
No. |
% |
No. |
% |
No. |
% |
No. |
% |
No. |
% |
| Carbamazepine |
4 |
7.7 |
3 |
4.6 |
6 |
15.8 |
5 |
16.7 |
10 |
11.1 |
8 |
8.4 |
| Clomethiazol |
0 |
0.0 |
2 |
3.1 |
0 |
0.0 |
0 |
0.0 |
0 |
0.0 |
2 |
2.1 |
| Clonazepam |
1 |
1.9 |
0 |
0.0 |
0 |
0.0 |
0 |
0.0 |
1 |
1.1 |
0 |
0.0 |
| Diazepam |
1 |
1.9 |
1 |
1.5 |
3 |
7.9 |
1 |
3.3 |
4 |
4.4 |
2 |
2.1 |
| Ethosuximide |
0 |
0.0 |
2 |
3.1 |
0 |
0.0 |
0 |
0.0 |
0 |
0.0 |
2 |
2.1 |
| Mephenytoin |
2 |
6.7 |
0 |
0.0 |
0 |
0.0 |
0 |
0.0 |
2 |
2.2 |
0 |
0.0 |
| Morsuximide |
1 |
1.9 |
0 |
0.0 |
1 |
2.6 |
0 |
0.0 |
2 |
2.2 |
0 |
0.0 |
| Phenacemide |
0 |
0.0 |
0 |
0.0 |
0 |
0.0 |
0 |
0.0 |
0 |
0.0 |
0 |
0.0 |
| Phenobarbital |
0 |
0.0 |
1 |
1.5 |
0 |
0.0 |
0 |
0.0 |
0 |
0.0 |
1 |
1.1 |
| Phenytoin |
11 |
1.2 |
13 |
20.0 |
8 |
21.1 |
1 |
3.3 |
19 |
21.1 |
14 |
14.7 |
| Primidone |
2 |
3.8 |
4 |
6.2 |
4 |
10.5 |
0 |
0.0 |
6 |
6.7 |
4 |
4.2 |
| Sultiame |
0 |
0.0 |
0 |
0.0 |
0 |
0.0 |
0 |
0.0 |
0 |
0.0 |
0 |
0.0 |
| Trimethadione |
0 |
0.0 |
1 |
1.5 |
1 |
2.6 |
0 |
0.0 |
1 |
1.1 |
1 |
1.1 |
| Valproate |
1 |
1.9 |
1 |
1.5 |
4 |
10.5 |
6 |
20.0 |
5 |
5.6 |
7 |
7.4 |
| Total |
23 |
44.2 |
28 |
43.1 |
27 |
71.1 |
13 |
43.3 |
50 |
55.6 |
41 |
43.2 |
| Polytherapy |
22 |
42.3 |
31 |
47.7 |
8 |
21.1 |
11 |
36.7 |
30 |
33.3 |
42 |
44.2 |
| No treatment |
7 |
13.5 |
6 |
9.2 |
3 |
7.9 |
6 |
20.0 |
10 |
11.0 |
12 |
12.6 |
| Grand total |
52 |
100.0 |
65 |
100.0 |
38 |
100.1 |
33 |
100.0 |
90 |
99.9 |
95 |
100.0 |