Table 1: Epidemiological manifestations, clinical signs and symptoms, laboratory and imaging examinations, echocardiographic and microbiological data of infective endocarditis in four intravenous drug users.

Epidemiological, Clinical, Laboratory, Radiological Data	Case 1	Case 2	Case 3	Case 4
Patient´s Age	33 years old	24 years old	30 years old	29 years old
Gender	Male	Male	Male	Male
Duration and Kind of Drug Consumption	11 years /Heroine	5 years/Heroine	9 years/Heroine	7 years/Heroine
Duration of Symptoms	5 days	18 days	23 days	6 days
Symptoms	cough, chest pain, fatigue, fever, myalgia, arthralgia.	cough, chest pain, dyspnea, fever, myalgia, arthralgia,.	cough, chest pain, fatigue, high fever, myalgia, arthralgia	high fever, myalgia, arthralgia, fatigue
Etiological Agent	Staph. aureus	Staph. Aureus	Staph. aureus	Staph. Aureus, Acinetobacilis baumani, Strept.pneumonie
HIV	negative	Negative	Negative	Negative
Valve and Type of Valve Involved, Number and Size Vegetations.	Tricuspid, native, 1 vegetation, 2.7cm2	Tricuspid, native, 1 vegetation, 2.87cm2	Tricuspid, native, multiple, 2-2.5 cm2	Tricuspid, native, 1 vegetation, 0.4 cm2
Vascular Phenomena	Septic pulmonary emboli	Septic pulmonary emboli	Septic pulmonary emboli, cutaneous vasculitis
Events Observed	Staphylococcic pneumonia, acute renal and hepatic failure, conjunctival hemorrhage	Staphylococcic pneumonia, Popliteal-femoral venous thrombosis	Staphylococcic pneumonia, acute cardiac, renal and hepatic failure, cutaneous vasculitis	Popliteal-femoral venous thrombosis
Comorbidity	No	Hepatitis C	Hepatitis B, Hepatitis C	Hepatitis C
Surgery	No	Yes	No	No
Death	No	No	No	No
Duration of Hosp.	54 days	43 days	63 days	23 days
Treatment	Vancomycin2g/day, Gentamycin 1 mg/kg every eight hours, Cefepime4g/day;	Vancomycin 2g/day, Merepenem3g/day	Vancomycin2g/day, Merepenem3g/day, Rifampicine 600mg/day;	Vancomycin2g/day, Gentamycin1 mg/kg every eight hours, Ceftriaxone 2g/day