Table 3: Comparison of Clinical Studies on HDAM and Hyper- CVAD

MSKCC HDAM MDACC CVAD NYMC HDAM NYMC CVAD
Patient No. 37 204 52 21
Median age (range) 39 (18-72) 39.5 (16-79) 35 (19-78) 29 (19-68)
Men 60% 65% 62% 52%
Ph+ 17% 16% 9% 5%
WBC 28 7.7 8 14
B 71% 76% 86% 52%
T 28% 18% 14% 34%
AlloSCT 9% NA 8% 14%
CR 83% 91% 87% 76%
Induction Death 9% 6% 9% 5%
Resistant disease 8% 3% 4% 19%
Time to CR(median) 32 21 29 27
5yr OS 35% 39% 30% NA
Median OS(months) 24 35 21 27
CR in Ph+ (No) 85% 91% 100%(6) 100%(1)
5yr OS in Ph+ 26% 7% NA NA

MSKCC: Memorial Sloan-Kettering Cancer Center; MDACC: MD Anderson Cancer Center; HDAM: high-dose AraC and Mitoxantrone; CVAD: Hyper-CVAD; NYMC: New York Medical College; NA:not available.