Table 2: Clinical Characteristics at HU Addition and Response

PTS AGE (at HU Addition) Ph+ Cells at HU Addition Mutational Status Response Time to Response (Months) Time to Relapse (Months) Follow-Up
1 35.9 100% NA CCR 32 4 Alive (Nilotinib→CCR)
2 66.6 100% NA Res / / BC after 16 mos→died
3 52.0 100% M244V Res / / Alive (Nilotinib→CCR)
4 57.4 100% NA Res / / Alive in CP
5 29.9 95% NA CCR 3 4 BC after 2 mos→died
6 48.4 100% F317L CCR 12 12 Alive in CP
7 52.9 100% L387F Res / / Alive in CP
8 54.1 80% NA MCR 7 4 Alive (Nilotinib→CCR)
9 57.4 66% Unmutated Res / / Alive (Nilotinib→CCR)
10 41.1 100% NA MCR 3 10 Alive after BMT
11 67.9 75% Unmutated CCR 7 / Alive in CMolR +23 mos

NA= Not assessed; CCR = Complete Cytogenetic Response; MCR = Major Cytogenetic Response; Res = Resistant; BP = Blastic Phase; CP = Chronic Phase; CMolR = Complete Molecular Response.