Table 1: Stimulation by Resiquimod of BAFF-R Expression in CLL Cells

Resiquimod (µM) D-Value (K-S Analysis) CLL Patient Case
1 2 3 4
0 0.53 0.51 0.48 0.55
1 0.67 0.87 0.82 0,79
5 0.70 0.91 0.83 0.85
10 0.71 0.92 0.84 0.89

Leukemia cells from four CLL patients (1, 2, 3, 4) were incubated in the presence of increasing concentrations of Resiquimod. After 48 h incubation, the expression of BAFF-R was determined by flow cytometry. D-values were estimated by Kolmogorov- Smirnov analysis and their increase in the presence of the various concentrations of Resiquimod were highly significant (at least p < 0.01).