| Parameters | del(5q) MDS [3] | Non del(5q) MDS [4] |
|---|---|---|
| Efficacy | ||
| RBC transfusion independence | 67% | 26% |
| Hematologic improvement by IWG 2006 criteria | 17% | |
| Median rise of hemoglobin | 5.4 g/dL | 3.2 g/dL |
| Median duration of transfusion independence | > 12 months | 41 weeks |
| Time to transfusion independence in 90% of responders | 3 months | 4 months |
| Cytogenetic responses (complete or > 50% reduction) | (45+28)% | (9+11)% |
| Safety | ||
| Grade 3 or 4 neutropenia | 53% | 55% |
| Grade 3 or 4 thrombocytopenia | 50% | 44% |