Fig. (1) Behavior of VEGF in a patient with POEMS syndrome (case report 2). After the first line chemotherapy the disease reached partial remission, accompanied by the decrease of VEGF. Subsequent peak was caused by 2-month therapy withdrawal and the second line treatment led again to the stabilization of the disease with a decrease of VEGF levels. The last course of VEGF suggests possible emerging progression of the disease. MIG – monoclonal immunoglobulin. VEGF – vascular endothelial growth factor. HD-ASCT – high dosed
chemotherapy with support of autologous stem cell transplant. Dotted line – upper limit for normal VEGF levels (707ng/L).