Table 1: Criteria of POEMS Syndrome – Mayo Clinic Criteria from 2003 [³] and 2007 [⁴]

Mayo Clinic Criteria 2003”*		“Mayo Clinic Criteria 2007”**		Associated Conditions
Major Criteria	Minor Criteria	Major Criteria	Minor Criteria
Polyneuropathy	Organomegaly: hepatomegaly, splenomegaly, lymphadenomegaly	Polyneuropathy	Organomegaly	Clubbing
Monoclonal plasma cell proliferative disorder	Edema (edema, pleural effusion, or)	Monoclonal plasma cell proliferative disorder	Edema	Weight loss
	Endocrinopathy (adrenal, thyroid,pituitary, gonadal, parathyroid, pancreatic)	Osteosclerotic bone lesions	Endocrinopathy	Thrombocytosis
	Skin changes (hyperpigmentation, hypertrichosis, hemangioms, plethora, acrocyanosis, flushing, white nails)	Castleman disease	Skin changes	Hyperhidrosis
	Papilledema	VEGF elevation	Papilledema	Pulmonary hypertension/restrictive lung disease
	Castleman disease			Diarrhea
	Osteoclerotic bone lesions			Low vitamin B12 level