Table 1: Criteria of POEMS Syndrome – Mayo Clinic Criteria from 2003 [3] and 2007 [4]

Mayo Clinic Criteria 2003”* “Mayo Clinic Criteria 2007”** Associated Conditions
Major Criteria Minor Criteria Major Criteria Minor Criteria
Polyneuropathy Organomegaly: hepatomegaly, splenomegaly, lymphadenomegaly Polyneuropathy Organomegaly Clubbing
Monoclonal plasma cell proliferative disorder Edema (edema, pleural effusion, or) Monoclonal plasma cell proliferative disorder Edema Weight loss
Endocrinopathy (adrenal, thyroid,pituitary, gonadal, parathyroid, pancreatic) Osteosclerotic bone lesions Endocrinopathy Thrombocytosis
Skin changes (hyperpigmentation, hypertrichosis, hemangioms, plethora, acrocyanosis, flushing, white nails) Castleman disease Skin changes Hyperhidrosis
Papilledema VEGF elevation Papilledema Pulmonary hypertension/restrictive lung disease
Castleman disease Diarrhea
Osteoclerotic bone lesions Low vitamin B12 level