Fig. (2) (A) Southern blot analysis of HTLV-I integration pattern for mononuclear cells and HU-ATTAK. Left panel shows patient PBMNC and the right panel shows the HU-ATTAK cell line derived from the same patient. E, EcoRI digestion and P, Pst1. The bands of the flanking sequence (thick arrows) are identical to each other. The three bands of internal sequences of HTLV-I (dotted arrows) were deleted, while a new band (open arrow) was detected in HU-ATTAK. (B) CGH analysis of original PBMNC and HU-ATTAK. The loci of amplification and deletion are shown.