Table 1: Selegiline (and methamphetamine) content of various body compartments of rats following p.o. treatment with 14C-labeled selegiline. All data are calculated using the calibration curve and from determination of radioactivity.
| Tissue or Body Fluid |
Selegiline (or methamphetamine) level, µg/ml or µg/g following 15 min |
Selegiline (or methamphetamine) level, µg/ml or µg/g following 30 min |
Selegiline (or methamphetamine) level, µg/ml or µg/g following 60 min |
Selegiline (or methamphetamine) level, µg/ml or µg/g following 120 min |
| Serum |
7.348 |
3.844 |
5.123 |
8.541 |
| Brain |
5.842 |
2.258 |
2.234 |
4.266 |
| Cochlea |
3.040 |
3.793 |
4.825 |
6.571 |
| Eyes |
2.123 |
1.364 |
2.850 |
2.245 |
| Lacrimal gland |
15.172 |
7.617 |
9.636 |
19.284 |
| Salivary gland |
5.764 |
3.332 |
5.080 |
6.414 |
| Testis |
3.264 |
2.354 |
2.259 |
3.923 |
| Kidney |
14.461 |
7.277 |
6.489 |
12.392 |
| Liver |
49.323 |
26.842 |
32.208 |
81.143 |
| Lung |
11.051 |
4.495 |
5.282 |
8.444 |
| Heart |
5.678 |
2.879 |
2.694 |
4.978 |
| Stomach |
263.229 |
98.048 |
106.372 |
77.322 |
| Urine |
--- |
474.172 |
90.512 |
769.814 |
| Faeces |
1.240 |
0.809 |
0.782 |
3.727 |