Table 2: Non-metabolized selegiline content of various body compartments of rats following p.o. treatment with 14C-labeled selegiline. All data are calculated using the HPLC.
Tissue or Body Fluid |
Selegiline level, µg/ml or µg/g following 15 min |
Selegiline level, µg/ml or µg/g following 30 min |
Selegiline level, µg/ml or µg/g following 60 min |
Selegiline level, µg/ml or µg/g following 120 min |
Serum |
2.06 |
1.51 |
1.66 |
2.20 |
Brain |
1.69 |
1.45 |
1.65 |
1.54 |
CSF |
1.50 |
1.96 |
1.64 |
1.53 |
Cochlea |
1.25 |
1.18 |
1.37 |
1.83 |
Eyes |
1.92 |
1.85 |
3.82 |
5.68 |
Lacrimal glands |
9.88 |
7.45 |
3.75 |
5.22 |
Salivary glands |
2.27 |
2.49 |
1.90 |
2.24 |
Testis |
2.01 |
1.88 |
1.86 |
2.03 |
Kidney |
9.81 |
6.87 |
2.48 |
4.60 |
Liver |
6.61 |
6.01 |
2.51 |
2.33 |
Lung |
4.56 |
3.47 |
3.62 |
3.99 |
Heart |
2.26 |
1.85 |
1.89 |
2.22 |
Stomach |
179.57 |
76.16 |
89.69 |
54.67 |