Fig. (3) Common pharmacophore generation and validation: (a) Common pharmacophore aligned ligands three acceptor [pink sphere with three arrows] and [one positive ionic (P) (dark blue)]; (b) common pharmacophoric bond distance of ligands with pharmacophoric atoms in Å unit; (c) alignment of all active ligands to the pharmacophore; and (d) alignment of three acceptors and one positive ionic pharmacophore with distance.