Table 5: In vitro antioxidant activity. Inhibitory activity of compounds on eeAcetylcholinesterase (eeAChE IC50 μΜ) and on esButyrylcholinesterase (esBuChE IC50 μΜ/%) of the tested compounds.
| Compds |
RA% @ 100μΜ |
∙ΟΗ % @ 100μΜ |
LP % @ 100μΜ |
%LOX @ 100μΜ or IC50 μΜ |
eeAChE % inhibn. @ 10 μΜ or IC50 μΜ |
esBChE % inhibn. @ 10 μΜ or IC50 μΜ |
| 4a |
nt |
nt |
63 |
6% |
nt |
nt |
| 4b |
nt |
nt |
no |
60 μΜ |
2.3 μΜ |
17% |
| 4c |
17 |
no |
65 |
no |
nt |
nt |
| 4d |
nt |
59 |
21 |
44.5% |
nt |
nt |
| 4e |
nt |
nt |
65 |
no |
nt |
nt |
| 4f |
3 |
no |
62 |
53 μΜ |
1.4 μΜ |
36% |
| 4g |
nt |
nt |
16 |
10% |
nt |
nt |
| 4i |
nt |
nt |
54 |
2% |
7.7 μΜ |
15% |
| 4j |
44 |
no |
32 |
37% |
nt |
nt |
| 4k |
12 |
27 |
57 |
10 μΜ |
nt |
nt |
| 4l |
12 |
90 |
37.5 |
61 μΜ |
nt |
nt |
| 4n |
17 |
no |
no |
35μΜ |
nt |
nt |
| 4o |
3 |
no |
40 |
60 μΜ |
nt |
nt |
| 11a |
nt |
nt |
44 |
no |
nt |
nt |
| 11b |
5 |
no |
no |
no |
5.9 μΜ |
8% |
| 11d |
13 |
no |
43 |
48μΜ |
nt |
nt |
| 11e |
nt |
nt |
63 |
no |
7.8 μΜ |
8% |
| 11f |
nt |
nt |
48 |
no |
43% |
14% |
| 11g |
nt |
nt |
no |
no |
nt |
nt |
| 13a |
no |
90 |
100 |
no |
40% |
23% |
| 13b |
no |
95 |
90 |
44% |
3.1 μΜ |
13% |
| 13d |
no |
79 |
no |
no |
nt |
nt |
| 13e |
no |
99 |
100 |
62 μΜ |
1.73 μΜ |
18 μM |
| 13f |
no |
100 |
23 |
25% |
nt |
nt |
| 13g |
no |
100 |
43 |
62 μΜ |
nt |
nt |
| 13h |
no |
97 |
86 |
55 μΜ |
nt |
nt |
| 13i |
no |
no |
74 |
76 μΜ |
5.0 μΜ |
18% |
| 15a |
no |
93 |
100 |
55 μΜ |
nt |
nt |
| 15b |
no |
48 |
52 |
100 μΜ |
nt |
nt |
| 15c |
no |
97 |
43 |
9% |
nt |
nt |
| 18a |
4 |
no |
No |
90 μΜ |
nt |
nt |
| 18b |
1 |
no |
38 |
100 μΜ |
nt |
nt |
| NDGA |
87 |
|
|
5.5 μΜ |
|
|
| Trolox |
|
83 |
76 |
|
|
|
| Galantamine |
|
|
|
|
0.51 μΜ |
8.7 μΜ |
No: no activity under the reported conditions; nt: not tested