Fig. (4) Compounds 8d (top) and 14 (bottom) docked into the active site of TcAChE (left) and possible ligands interactions with conserved aromatic residues (right). Compounds 8d and 14 below are shown in white. In pink and cyan are Trp84 (CAS) and Trp 279 (PAS), crucial amino acids regularly involved in inhibition of AChE.