Scheme 1 Reagents and conditions: (a) anthranilic acid (1), cyclohexanone (2), toluene, reflux, 4 hrs; (b) spiro[2H-3,1-benzoxazine-2,1-cyclohexane]-4(1H)-one (3), POCl₃, alkaline workup (KOH), 2 hrs; (c) 9-chloro-1,2,3,4-tetrahydroacridine (4), alkylenediamines in excess (5n), DCM, NaHCO₃, microwave irradiation at 200 ⁰C, 250 W and maximum pressure for 30 minutes; (d) N¹-(1,2,3,4-tetrahydroacridin-9-yl)-alkane-1,n-diamine (6n), Trolox (7), N,N-carbonyldiimidazole, THF, rt, overnight, giving the tacrine-trolox hybrids (8a – 8d).