Table 1: Preliminary anti-HCV activity of the synthesized compounds 3-12 on HepG 2.

Compound No. IC50a)
(µg/mL) 		EC99b)
(µg/mL) 		Anti-HCV Activityc)
3a 5.64 0.10 positive
3b 6.60 0.12 negative
4 5.50 0.11 negative
5 8.77 0.17 negative
6 14.33 0.27 positive
7a 6.50 0.12 positive
7b 4.37 0.08 positive
7c 10.40 0.20 negative
9a 8.46 0.16 positive
9b 18.16 0.36 positive
10a 6.80 0.13 positive
10b 7.80 0.14 negative
10c 4.20 0.08 negative
10d 5.75 0.11 negative
10e 4.23 0.08 negative
10f 9.45 0.18 negative
11a 5.30 0.10 negative
11b 7.04 0.13 positive
12a 8.10 0.15 negative
12b 12.16 0.23 negative

a) IC50: concentration of the compound that caused 50% death of cells.
b) EC99: concentration of the compound that maintained 90-99% viability of cells.
c) Ability to inhibit the replication of both HCV RNA (+) and (–) strands.