Fig. (4) RNS production after 24 h of exposure to vehicle (negative control), ABQ-48 (50 µM), NBQ-48 (100 µM), camptothecin (PC, positive control, 50 µM) and Cisplatin (CS, positive control, 40 µM) was determined. Cells exposed to ABQ-48, and PC exhibited significant induction of reactive nitrogen species (RNS) production on CRL2631 cells when compared to the negative control. Statistical analysis performed was one way ANOVA, with Tukey post hoc test, where p <0.05 was considered to be significant. P summary; significantly different from negative control group (p <0.0001), ns = no significant difference from negative control group (p > 0.05). Results percent (%) was calculated by negative control normalization.