Fig. (8) Summary of detected apoptosis related events on Toledo Lymphoma cells after treatment with ABQ-48 and NBQ-48. Results suggest difference in the mechanisms of action. ABQ-48 induced caspase independent with probable downstream caspase activation while NBQ-48 can induce caspase dependent cell death. Mitochondrial membrane permeabilization (MMP), reactive oxygen species (ROS), reactive nitrogen species (RNS), DNA fragmentation (DNA Frag), Apoptosis inducing factor (AIF).