Table 1: ARL2 inhibitory activities of compounds 1-10.

     Compounds      N      Y      X      R      R′      IC50 (μM)a
     Sorbinil      0.65
     1b      0      CO      H      4-OMe-Ph      H      2.25
     2b      0      CO      Br      4-OMe-Ph      H      0.58
     3      1      CO      H      4-OMe-Ph      Me      n.a.
     4      1      CO      Br      4-OMe-Ph      Me      4.97
     5      0      CO      H      Me      Me      42.3
     6      0      CO      Br      Me      Me      17.3
     7      1      CO      H      Me      Me      2.00
     8      1      CO      Br      Me      Me      n.a.
     9      1      CH2      H      Me      Me      n.a.
     10      1      CH2      Br      Me      Me      4.17

aIC50 values represent the concentration required to produce 50% enzyme inhibition. Standard error of the mean (SEM) is ≤ 10. bSee reference [17]. n.a.: not active. No inhibition was observed up to 100 μM of test compounds.